https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Cocaine- and amphetamine-regulated transcript (CART) signaling within the paraventricular thalamus modulates cocaine-seeking behaviour https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11120 Wed 11 Apr 2018 13:59:42 AEST ]]> Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14350 +). The effect of VTA-directed injections of SB-334867 (0 or 3 μg) on locomotor activity was also assessed. Intra-VTA, but not -PVT, SB-334867 dose-dependently attenuated S⁺-induced reinstatement (3 μg dose, p<0.01). Intra-VTA SB-334867 had no effect on locomotor activity. We conclude that OrxR1 signalling within the VTA, but not the PVT, mediates cue-induced cocaine-seeking behaviour. We hypothesize that blockade of VTA OrxR1 signalling may reduce nucleus accumbens dopamine in response to drug cue presentation.]]> Wed 11 Apr 2018 11:48:59 AEST ]]> Rapamycin reduces motivated responding for cocaine and alters GluA1 expression in the ventral but not dorsal striatum https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27809 Wed 02 Mar 2022 14:24:39 AEDT ]]> mTORC1 inhibition in the nucleus accumbens 'protects' against the expression of drug seeking and 'relapse' and is associated with reductions in GluA1 AMPAR and CAMKIIα levels https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20866 Sat 24 Mar 2018 07:57:51 AEDT ]]>